Human Tissue Research Network

i-Path

Publish date: 29/03/11

i-Path provides leading software solutions for web-based digital pathology, project management services,  Image Analysis and TMA. 

•    Better digital pathology performance  using i-Path’s high performance image servers
•    Slide Scanning by experienced technical staff and scientists
•    Ability to share slides instantly with collaborators anywhere in the world at any time
•    High level security
•    World wide server infrastructure
•    Time and cost savings
•    Tissue Microarray management and scoring solutions
•    Tissue and Cell Image Analysis Solutions

Come and meet i-Path at the Human Tissue Research Network Summit 2011

Duolink Technology Enables Protein Interaction and Modification Detection

Publish date: 05/01/11

The Duolink® in situ Proximity Ligation Assay (PLA™) from Olink Bioscience enables the in-situ detection and visualisation of individual proteins, protein modifications and protein complexes in tissue and cell samples prepared for microscopy.

The target is recognised using two antibodies, which are conjugated with oligos which when in close proximity, combine to form a DNA template which can be amplified by rolling circle amplification.

Detection kits include either fluorescent- or HRP-tagged oligos which hybridise with the amplified DNA.

The signal from each detected pair of primary antibodies is then visualised as individual spots. The number of detection events can be quantified (counted) and assigned to a specific sub-cellular location based on microscopy images.

A introductory movie can be viewed here

To find out more, please Click Here

AQIX RS-I: New Solution Keeps Human Tissue & Cells Alive for Days

Publish date: 04/01/11

AQIX RS-I is a unique solution  that sustains human tissue, alive, ex-vivo. Tissues held in this solution show a minimal loss of viability and function over time and are more representative of in vivo activity than samples collected by traditional preservative methods.

Benefits of AQIX RS-I

• Increases the availability of fresh human tissue through reduced sample failures
• Increases transportation time windows
• Maintains pharmacology and morphology of intact organs, tissues and cells

To find out more, please Click Here

Cryosettes® Tissue Sample Management Devices

Publish date: 03/01/11

Cryosettes® are robust tissue sample management devices for the efficient storage and tracking of frozen human biospecimens.

Up to 8400 Cryosettes® can be contained in a single -80oC freezer, maximizing storage capacity.  Cryosettes® are also suitable for use in both mechanical and vapor phase liquid nitrogen freezers.

The devices are compliant with standard sample shipping regulations making them ideal for the transport of samples. Their structure and labelling method will optimize tissue management and maximize the productivity of tissue banks.

Please Click Here for more information

FDA Tissue Panels

Publish date: 02/01/11

FDA guidance on the testing of monoclonal antibody or peptide therapeutic products for human use highlights the risk potential when the same or related antigenic determinant as targeted by the therapeutic antibody or peptide is expressed on human cells or tissues other than the intended target tissue. 

Cross-reactivity studies with human tissues should be conducted to search for cross-reactions or non-target tissue binding to screen for polymorphisms on:
-  A panel of normal, non-diseased Human cells or tissues with quick-frozen adult tissues and
- Tissues from at least three unrelated human donors.

We can provide all 32 of the snap frozen human tissues required to undertake a cross reactivity study of this kind. Samples are ethically sourced and are tested for appropriate morphology in frozen and fixed tissue formats.

For more information, please Click Here